2-Bromoacetamide
Names
[ CAS No. ]:
683-57-8
[ Name ]:
2-Bromoacetamide
[Synonym ]:
Bromoacetamide
EINECS 226-270-1
Acetamide, 2-bromo-
MFCD00008025
2-Bromoacetamide
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Boiling Point ]:
271.6±23.0 °C at 760 mmHg
[ Melting Point ]:
87-91 °C(lit.)
[ Molecular Formula ]:
C2H4BrNO
[ Molecular Weight ]:
137.963
[ Flash Point ]:
118.1±22.6 °C
[ Exact Mass ]:
136.947617
[ PSA ]:
43.09000
[ LogP ]:
-0.52
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.511
[ Storage condition ]:
Store at RT.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AB4587000
- CHEMICAL NAME :
- Acetamide, 2-bromo-
- CAS REGISTRY NUMBER :
- 683-57-8
- BEILSTEIN REFERENCE NO. :
- 1739073
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C2-H4-Br-N-O
- MOLECULAR WEIGHT :
- 137.98
- WISWESSER LINE NOTATION :
- ZV1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 124 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(8),54,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >102 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(8),54,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 61 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(8),54,1981
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H314
[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T,C
[ Risk Phrases ]:
R25;R34
[ Safety Phrases ]:
S26-S27-S36/37/39-S45
[ RIDADR ]:
UN 2923 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AB4587000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2924199013
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199013
[ Summary ]:
HS:2924199013 2-bromoacetamide VAT:17.0% Tax rebate rate:0.0% Supervision conditions:S MFN tariff:6.5% General tariff:30.0%
Articles
ChemMedChem 10(1) , 62-7, (2014)
Clinically there is a need for local anesthetics with a greater specificity of action on target cells and longer duration. We have synthesized a series of local anesthetic derivatives we call boronica...
(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.J. Med. Chem. 48(6) , 1745-58, (2005)
A series of ring-constrained (N)-methanocarba-5'-uronamide 2,N(6)-disubstituted adenine nucleosides have been synthesized via Mitsunobu condensation of the nucleobase precursor with a pseudosugar ring...
Kinetic analysis of sequence-specific alkylation of DNA by pyrimidine oligodeoxyribonucleotide-directed triple-helix formation.Bioconjug. Chem. 8(3) , 354-64, (1997)
Attachment of a nondiffusible bromoacetyl electrophile to the 5-position of a thymine at the 5'-end of a pyrimidine oligodeoxyribonucleotide affords sequence-specific alkylation of a guanine base in d...