VO-OHpic

Modify Date: 2025-08-26 20:49:33

VO-OHpic structure	Common Name	VO-OHpic
	CAS Number	675848-25-6	Molecular Weight	361.16
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₀N₂O₈V	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VO-OHpic

VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].

Name	VO-OHpic
Synonym	More Synonyms

Description	VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> PTEN Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 46 nM (PTEN)[1]
References	[1]. Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63. doi: 10.1007/s12154-010-0041-7. Epub 2010 Jun 4. [2]. Johnson TA, et al. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1236-H1249. [3]. Wang W, et al. PTEN inhibitor VO-OHpic suppresses TSC2-/- MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway. Exp Ther Med. 2020 Jun;19(6):3565-3570.

Molecular Formula	C₁₂H₁₀N₂O₈V
Molecular Weight	361.16
InChIKey	DUQTXODYOYERFR-UHFFFAOYSA-N
SMILES	O=C(O)c1ncccc1O.O=C(O)c1ncccc1O.O=[V][O-]

(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen

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VO-OHpic

Use of VO-OHpic

Names

VO-OHpic Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.