VO-OHpic

Modify Date: 2024-01-14 08:51:49

VO-OHpic structure	Common Name	VO-OHpic
	CAS Number	675848-25-6	Molecular Weight	361.16
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₀N₂O₈V	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VO-OHpic

VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].

Name	VO-OHpic
Synonym	More Synonyms

Description	VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> PTEN Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 46 nM (PTEN)[1]
References	[1]. Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63. doi: 10.1007/s12154-010-0041-7. Epub 2010 Jun 4. [2]. Johnson TA, et al. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1236-H1249. [3]. Wang W, et al. PTEN inhibitor VO-OHpic suppresses TSC2-/- MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway. Exp Ther Med. 2020 Jun;19(6):3565-3570.

Molecular Formula	C₁₂H₁₀N₂O₈V
Molecular Weight	361.16

(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen

VO-OHpic

Use of VO-OHpic

Names

VO-OHpic Biological Activity

Chemical & Physical Properties

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