VO-OHpic

Names

[ Name ]:
VO-OHpic

[Synonym ]:
(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen

Biological Activity

[Description]:

VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> PI3K/Akt/mTOR >> PTEN

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[Target]

IC50: 46 nM (PTEN)[1]

[References]

[1]. Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63. doi: 10.1007/s12154-010-0041-7. Epub 2010 Jun 4.

[2]. Johnson TA, et al. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1236-H1249.

[3]. Wang W, et al. PTEN inhibitor VO-OHpic suppresses TSC2-/- MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway. Exp Ther Med. 2020 Jun;19(6):3565-3570.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀N₂O₈V

[ Molecular Weight ]:
361.16

Related Compounds

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