GBR 12783 dihydrochloride

Modify Date: 2024-04-03 19:10:03

GBR 12783 dihydrochloride structure	Common Name	GBR 12783 dihydrochloride
	CAS Number	67469-57-2	Molecular Weight	485.488
	Density	1.085 g/cm3	Boiling Point	550.5ºC at 760 mmHg
	Molecular Formula	C₂₈H₃₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	148.1ºC

Use of GBR 12783 dihydrochloride

GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats[1][2].

Name	1-(2-benzhydryloxyethyl)-4-(3-phenylprop-2-enyl)piperazine,dihydrochloride
Synonym	More Synonyms

Description	GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vivo	GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; for 100 minutes Result: For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
References	[1]. Nail-Boucherie K, et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5. [2]. Bonnet JJ, et al. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur J Pharmacol. 1986 Feb 18;121(2):199-209.

Density	1.085 g/cm3
Boiling Point	550.5ºC at 760 mmHg
Molecular Formula	C₂₈H₃₂N₂O
Molecular Weight	485.488
Flash Point	148.1ºC
Exact Mass	484.204834
PSA	15.71000
LogP	6.60340
Index of Refraction	1.601
Storage condition	-20°C

HS Code	2933599090

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride

1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine dihydrochloride

Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:2)

DC Chemicals Limited
China
Product Name: GBR12783
Price: $300.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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