68941-21-9

68941-21-9 structure

Name: SKF 91488 dihydrochloride
Chemical Name: Homodimaprit dihydrochloride
CAS Number: 68941-21-9
Molecular Formula: C₇H₁₉Cl₂N₃S
Molecular Weight: 248.22
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2018-02-21 13:26:49
Modify Date: 2024-04-05 19:33:47
SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice[1].

Name	Homodimaprit dihydrochloride
Synonyms	S-(4-dimethylamino-butyl)-isothiourea, dihydrochloride S-(4-Dimethylamino-butyl)-isothioharnstoff, Dihydrochlorid S-[4-(dimethylamino)butyl]isothiourea dihydrochloride

Description	SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Neurological Disease
References	[1]. Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9(5-6):455-60.