Fenoldopam
Modify Date: 2024-01-03 11:47:48
Fenoldopam structure
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Common Name | Fenoldopam | ||
|---|---|---|---|---|
| CAS Number | 67227-56-9 | Molecular Weight | 305.756 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 522.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H16ClNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 269.9±30.1 °C | |
Use of FenoldopamFenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2]. |
| Name | fenoldopam |
|---|---|
| Synonym | More Synonyms |
| Description | Fenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 522.6±50.0 °C at 760 mmHg |
| Molecular Formula | C16H16ClNO3 |
| Molecular Weight | 305.756 |
| Flash Point | 269.9±30.1 °C |
| Exact Mass | 305.081879 |
| PSA | 72.72000 |
| LogP | 1.72 |
| Appearance of Characters | off-white |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.656 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: >12 mg/mL |
| Hazard Codes | Xn:Harmful; |
|---|---|
| Risk Phrases | R22;R36;R42/43 |
| Safety Phrases | S22-S26-S36/37/39 |
| WGK Germany | 3 |
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Fenoldopam CAS#:67227-56-9 |
| Literature: US2006/194967 A1, ; Page/Page column 7-8 ; |
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Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
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Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
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Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
|
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Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
|
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Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
|
~%
Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
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Fenoldopam CAS#:67227-56-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975 |
![N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine structure](https://www.chemsrc.com/caspic/107/71636-38-9.png)
| Precursor 8 | |
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| DownStream 1 | |
CAS#:67227-57-0| skf 82526-j |
| MFCD04112986 |
| 2,3,4,5-tetrahydro-6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-1H-3-benzoazepine |
| Corlopam |
| CORLOPAM MESYLATE |
| 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine |
| 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)- |
| (r)-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1h-3-benzazepine-7,8-diol |
| 6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine |
| 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(4-HYDROXYPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL MESYLATE |
| Fenoldopam |
| EINECS 266-612-7 |
| FENOLDOPAM HYDROCHLORIDE |
| 6-Chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol |
| 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol |
| 6-Chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-tetrahydro-1H-3-benzazepine |