Fenoldopam hydrochloride

Modify Date: 2025-08-26 11:48:34

Fenoldopam hydrochloride structure	Common Name	Fenoldopam hydrochloride
	CAS Number	181217-39-0	Molecular Weight	342.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₇Cl₂NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Fenoldopam hydrochloride

Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

Name	Fenoldopam Hydrochloride
Synonym	More Synonyms

Description	Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Epigenetics >> Histone Demethylase Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Target	IC50: 0.8974 μM (LSD1)[2]
References	[1]. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. [2]. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561. [3]. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.

Molecular Formula	C₁₆H₁₇Cl₂NO₃
Molecular Weight	342.22
Exact Mass	341.05900
PSA	72.72000
LogP	3.86520

9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride

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Fenoldopam hydrochloride

Use of Fenoldopam hydrochloride

Names

Fenoldopam hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.