PG 931 TFA structure
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Common Name | PG 931 TFA | ||
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CAS Number | 667430-81-1 | Molecular Weight | 1180.40 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C59H85N15O11 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of PG 931 TFAPG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2]. |
Name | PG-931 |
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Description | PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2]. |
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Related Catalog | |
Target |
IC50: 0.58 nM (melanocortin 4 receptor) IC50: 2.4 nM (melanocortin 5 receptor) IC50: 55 nM (melanocortin 3 receptor)[1] |
In Vivo | PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock[2]. Animal Model: Wistar rats[2] Dosage: 13-108 nmol/kg Administration: Intravenous injection; single dose Result: Exhibitd an anti-shock effect occurred at nanomolar doses. |
References |
Molecular Formula | C59H85N15O11 |
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Molecular Weight | 1180.40 |
Storage condition | -20°C |