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  • DC Chemicals Limited
  • China
  • Product Name: PG-S3-001
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2047372-50-7

2047372-50-7 structure
2047372-50-7 structure
  • Name: PG-S3-001
  • Chemical Name: PG-S3-001
  • CAS Number: 2047372-50-7
  • Molecular Formula: C32H33F5N2O5S
  • Molecular Weight: 652.677
  • Create Date: 2020-01-12 13:17:51
  • Modify Date: 2024-04-02 18:46:38
  • PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.

Name PG-S3-001
Description PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
References References 1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805. View Related Products by Target STAT
Molecular Formula C32H33F5N2O5S
Molecular Weight 652.677