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1681056-62-1

1681056-62-1 structure

1681056-62-1 structure

Name: PG 34
Chemical Name: PG 34
CAS Number: 1681056-62-1
Molecular Formula: C₂₈H₂₅N₃O₅S₂
Molecular Weight: 547.65
Catalog: Research Areas Others
Create Date: 2022-10-12 20:09:08
Modify Date: 2025-09-18 08:50:45
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738)[1].

Name	PG 34

Description	PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	PG34 (0.5-50 µM; 24 h) shows no detectable inhibition of OGT in CHO cells, displays no effect on apoptotic signaling, and shows a moderate effect on cell viability only at the highest concentration[1]. Cell Viability Assay[1] Cell Line: CHO cells Concentration: 0.5-50 µM Incubation Time: 24 hours Result: Inhibited cell growth moderately at 50 µM. Western Blot Analysis[1] Cell Line: CHO cells Concentration: 10, 25, and 50 µM Incubation Time: 24 hours Result: Showed no reduction in global O-GlcNAcylation in cells.
References	[1]. Rodrigo F Ortiz-Meoz, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.

Molecular Formula	C₂₈H₂₅N₃O₅S₂
Molecular Weight	547.65

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