TRPM4-IN-2

Modify Date: 2024-01-14 19:26:56

TRPM4-IN-2 Structure
TRPM4-IN-2 structure
 Common Name TRPM4-IN-2
CAS Number 667411-04-3 Molecular Weight 355.77
Density N/A Boiling Point N/A
Molecular Formula C19H14ClNO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TRPM4-IN-2


TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

 Names

Name TRPM4-IN-2

 TRPM4-IN-2 Biological Activity

Description TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].
Related Catalog
Target

TRPM4:0.16 μM (IC50)

In Vitro TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1]. Cell Proliferation Assay[1] Cell Line: DU145 Concentration: 50 μM Incubation Time: 0-500 s Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
References

[1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665.

[2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400.

 Chemical & Physical Properties

Molecular Formula C19H14ClNO4
Molecular Weight 355.77
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Chemsrc provides TRPM4-IN-2(CAS#:667411-04-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TRPM4-IN-2 are included as well.>> amp version: TRPM4-IN-2

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