Bisoprolol

Modify Date: 2024-01-05 09:35:40

Bisoprolol Structure
Bisoprolol structure
Common Name Bisoprolol
CAS Number 66722-44-9 Molecular Weight 325.443
Density 1.0±0.1 g/cm3 Boiling Point 445.0±45.0 °C at 760 mmHg
Molecular Formula C18H31NO4 Melting Point N/A
MSDS Chinese USA Flash Point 222.9±28.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Bisoprolol


Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].

 Names

Name bisoprolol
Synonym More Synonyms

 Bisoprolol Biological Activity

Description Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].
Related Catalog
Target

β1-adrenergic receptor[1]

References

[1]. Jillian G Baker, et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22.

[2]. Maria Hoeltzenbein, et al. Pregnancy outcome after first trimester exposure to bisoprolol: an observational cohort study. J Hypertens. 2018 Oct;36(10):2109-2117.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 445.0±45.0 °C at 760 mmHg
Molecular Formula C18H31NO4
Molecular Weight 325.443
Flash Point 222.9±28.7 °C
Exact Mass 325.225311
PSA 59.95000
LogP 2.14
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.500

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UB8380000
CHEMICAL NAME :
2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1 -methylethyl)amino)-
CAS REGISTRY NUMBER :
66722-44-9
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H31-N-O4
MOLECULAR WEIGHT :
325.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
143 ug/kg
TOXIC EFFECTS :
Cardiac - change in rate
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 9,255,1990

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
RTECS UB8380000
HS Code 2922509090

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles18

More Articles
High throughput quantification of prohibited substances in plasma using thin film solid phase microextraction.

J. Chromatogr. A. 1374 , 40-9, (2014)

Simple, fast and efficient sample preparation approaches that allow high-throughput isolation of various compounds from complex matrices are highly desired in bioanalysis. Particularly sought are meth...

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1363 , 226-235, (2014)

The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method ...

β-Blockers promote angiogenesis in the mouse aortic ring assay.

J. Cardiovasc. Pharmacol. 64(1) , 21-7, (2014)

Recent results indicate that the reduction of β-adrenergic signaling impairs angiogenesis under ischemic conditions. Because angiogenesis may occur in the absence of ischemia, it remains to be determi...

 Synonyms

1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol
(±)-1-[p-(2-Isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2-propanol
1-(propan-2-ylamino)-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol
Bisoprolol
1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol
2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-
MFCD00865795
1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
(±)-1-[[a-(2-Isopropoxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol
1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol
1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol
2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: Bisoprolol
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

Get all suppliers and price by the below link:

Bisoprolol suppliers

Bisoprolol price