Bisoprolol Fumarate
Modify Date: 2024-01-02 18:25:36
Bisoprolol Fumarate structure
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Common Name | Bisoprolol Fumarate | ||
|---|---|---|---|---|
| CAS Number | 104344-23-2 | Molecular Weight | 766.96 | |
| Density | 1.033 g/cm3 | Boiling Point | 445ºC at 760 mmHg | |
| Molecular Formula | C40H66N2O12 | Melting Point | 100ºC | |
| MSDS | Chinese USA | Flash Point | 222.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Bisoprolol FumarateBisoprolol is a selective type β1 adrenergic receptor blocker.Target: Adrenergic ReceptorApproved: July 31, 1992Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol [1]. Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) [2].Toxicity: Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat. |
| Name | bisoprolol fumarate |
|---|---|
| Synonym | More Synonyms |
| Description | Bisoprolol is a selective type β1 adrenergic receptor blocker.Target: Adrenergic ReceptorApproved: July 31, 1992Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol [1]. Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) [2].Toxicity: Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat. |
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| Related Catalog | |
| References |
| Density | 1.033 g/cm3 |
|---|---|
| Boiling Point | 445ºC at 760 mmHg |
| Melting Point | 100ºC |
| Molecular Formula | C40H66N2O12 |
| Molecular Weight | 766.96 |
| Flash Point | 222.9ºC |
| PSA | 134.55000 |
| LogP | 2.46860 |
| Appearance of Characters | solid | white |
| Vapour Pressure | 1.06E-08mmHg at 25°C |
| Water Solubility | DMSO: >20 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UB8390000 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Regulation by bisoprolol for cardiac microRNA expression in a rat volume-overload heart failure model.
J. Nanosci. Nanotechnol. 13(8) , 5267-75, (2013) Emerging evidence suggests the involvement of altered microRNA (miRNA) regulation in heart failure pathogenesis. We established a rat volume-overload heart failure model, and examined miRNA expression... |
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Bioequivalence study of 2 formulations of film-coated tablets containing a fixed dose combination of bisoprolol fumarate 5 mg and hydrochlorothiazide 6.25 mg in healthy subjects.
Drug Res. (Stuttg.) 63(5) , 243-9, (2013) The present study was conducted to compare the bioavailability of 2 formulations of fixed-dose combination of bisoprolol fumarate 5 mg and hydrochlorotiazide (HCT) 6.25 mg film-coated tablet (test and... |
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[Telangiectasia during amlodipine therapy].
Ann. Dermatol. Venereol. 140(3) , 202-5, (2013) Calcium inhibitors are recommended as first-line treatment in hypertension. We report the development of telangiectasia on the trunk and upper limbs in a female patient on amlodipine (Amlor(®)) that s... |
| 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt) |
| Concor |
| Bisoprolol fumarate |
| Isoten |
| acide (2E)-but-2-ènedioïque - 1-(4-{[2-(1-méthyléthoxy)éthoxy]méthyl}phénoxy)-3-[(1-méthyléthyl)amino]propan-2-ol (1:2) |
| (2E)-But-2-endisäure--1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol(1:2) |
| Monocor |
| {1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol}2 fumarate |
| (+/-)-1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methyl-ethyl)amino]-2-propanol (E)-2-butenedioate |
| EMCOR |
| Euradal |
| SOPROL |
| Bisoprolol hemifumarate |
| 1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol (2E)-but-2-enedioate (2:1) |
| (±)-Bisoprolol hemifumarate |
| 1-(propan-2-ylamino)-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol (2E)-but-2-enedioate (2:1) |
| 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1) (salt) |
| Zebeta |
| Detensiel |
| Seafuri |
| MFCD00792743 |
| (+/-)-1-<4-(2-isopropoxyethoxymethyl)-phenoxy>-3-isopropylamino-2-propanol hemifumarate |
| 1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol (2E)-2-butenedioate (2:1) |
| Bisoprolol hemifumarate salt |
| Emconcor |
| Well-bi |
| (±)-Bisoprolol (hemifumarate) |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Bisoprolol Fumarate
- Price: ￥1018.0/5mg ￥3738.0/25mg ￥10458.0/100mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Bisoprolol Fumarate
- Price: $Inquiry/100mg $Inquiry/250mg $400.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Bisoprolol Fumarate
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Bisoprolol fumarate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: $90/10mM*1mLinDMSO
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