1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
Modify Date: 2024-01-09 12:43:13
![1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane Structure](https://www.chemsrc.com/caspic/102/66504-40-3.png)
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane structure
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Common Name | 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane | ||
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| CAS Number | 66504-40-3 | Molecular Weight | 228.12 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H11Cl2N | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexaneDOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2]. |
| Name | 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane |
|---|---|
| Synonym | More Synonyms |
| Description | DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2]. |
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| Related Catalog | |
| Target |
IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine)[1]. |
| In Vivo | Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals[2]. Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations[2]. Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2]. Dosage: 20 mg/kg. Administration: I.P. daily for 17days. Result: Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations. Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2]. Dosage: 20 mg/kg. Administration: I.P. once. Result: Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals. |
| References |
| Molecular Formula | C11H11Cl2N |
|---|---|
| Molecular Weight | 228.12 |
| Exact Mass | 227.02700 |
| PSA | 12.03000 |
| LogP | 3.18310 |
| Storage condition | 2-8℃ |
![1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione structure](https://www.chemsrc.com/caspic/450/66504-44-7.png)
| dotriacontanedioic acid dichloride |
| dotricontanedioyl dichloride |
| Dotriacontan-disaeure-dichlorid |