Acyclovir monophosphate

Modify Date: 2025-08-24 12:47:47

Acyclovir monophosphate Structure
Acyclovir monophosphate structure
 Common Name Acyclovir monophosphate
CAS Number 66341-16-0 Molecular Weight 305.185
Density 2.1±0.1 g/cm3 Boiling Point 716.0±70.0 °C at 760 mmHg
Molecular Formula C8H12N5O6P Melting Point >400ºC
MSDS N/A Flash Point 386.8±35.7 °C

 Use of Acyclovir monophosphate


Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].

 Names

Name Acyclovir Monophosphate
Synonym More Synonyms

 Acyclovir monophosphate Biological Activity

Description Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].
Related Catalog
References

[1]. Yao J, et al. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. J Control Release. 2013 Sep 28;170(3):414-20.

[2]. Elion GB, et al. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73(1A):7-13.

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 716.0±70.0 °C at 760 mmHg
Melting Point >400ºC
Molecular Formula C8H12N5O6P
Molecular Weight 305.185
Flash Point 386.8±35.7 °C
Exact Mass 305.052521
PSA 175.39000
LogP -2.21
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.780

 Synonyms

2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl dihydrogen phosphate
6H-Purin-6-one, 2-amino-3,9-dihydro-9-[[2-(phosphonooxy)ethoxy]methyl]-
Acyclovir monophosphate
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