Acyclovir monophosphate

Names

[ Name ]:
Acyclovir monophosphate

[Synonym ]:
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl dihydrogen phosphate
6H-Purin-6-one, 2-amino-3,9-dihydro-9-[[2-(phosphonooxy)ethoxy]methyl]-
Acyclovir monophosphate

Biological Activity

[Description]:

Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

[References]

[1]. Yao J, et al. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. J Control Release. 2013 Sep 28;170(3):414-20.

[2]. Elion GB, et al. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73(1A):7-13.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
716.0±70.0 °C at 760 mmHg

[ Melting Point ]:
>400ºC

[ Molecular Formula ]:
C₈H₁₂N₅O₆P

[ Molecular Weight ]:
305.185

[ Flash Point ]:
386.8±35.7 °C

[ Exact Mass ]:
305.052521

[ PSA ]:
175.39000

[ LogP ]:
-2.21

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.780

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.