5'-Deoxy-5-fluorocytidine

Modify Date: 2025-08-22 17:31:12

5'-Deoxy-5-fluorocytidine Structure
5'-Deoxy-5-fluorocytidine structure
 Common Name 5'-Deoxy-5-fluorocytidine
CAS Number 66335-38-4 Molecular Weight 245.21
Density 1.8±0.1 g/cm3 Boiling Point 437.9±55.0 °C at 760 mmHg
Molecular Formula C9H12FN3O4 Melting Point 196-198ºC
MSDS N/A Flash Point 218.6±31.5 °C

 Use of 5'-Deoxy-5-fluorocytidine


5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

 Names

Name 5'-Deoxy-5-fluorocytidine
Synonym More Synonyms

 5'-Deoxy-5-fluorocytidine Biological Activity

Description 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Related Catalog
References

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 437.9±55.0 °C at 760 mmHg
Melting Point 196-198ºC
Molecular Formula C9H12FN3O4
Molecular Weight 245.21
Flash Point 218.6±31.5 °C
Exact Mass 245.081177
PSA 110.60000
LogP -0.94
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.700
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 Safety Information

Hazard Codes Xn: Harmful;Xi: Irritant;
Risk Phrases R20/21/22
Safety Phrases 26-36-37/39
RIDADR NONH for all modes of transport
HS Code 2934999090

 Synthetic Route

Capecitabine structure

Capecitabine

CAS#:154361-50-9

~92%

5'-Deoxy-5-fluorocytidine Structure

5'-Deoxy-5-fluo...

CAS#:66335-38-4

Literature: ANGIOGENE PHARMACEUTICALS LIMITED; THE GRAY LABORATORY CANCER RESEARCH TRUST Patent: WO2006/32921 A1, 2006 ; Location in patent: Page/Page column 37-38 ;
2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine structure

2',3'-Di-O-acet...

CAS#:161599-46-8

~95%

5'-Deoxy-5-fluorocytidine Structure

5'-Deoxy-5-fluo...

CAS#:66335-38-4

Literature: MacDonald, Peter Lindsay; Rossetto, Pierluigi; Gallina, Maurizio Patent: US2009/209754 A1, 2009 ; Location in patent: Page/Page column 9-10 ;
5'-Deoxy-5-fluoro-2',3'-O-isopropylidene-D-cytidine structure

5'-Deoxy-5-fluo...

CAS#:66335-37-3

~86%

5'-Deoxy-5-fluorocytidine Structure

5'-Deoxy-5-fluo...

CAS#:66335-38-4

Literature: Procopio, Antonio; Gaspari, Marco; Nardi, Monica; Oliverio, Manuela; Romeo, Roberto Tetrahedron Letters, 2008 , vol. 49, # 12 p. 1961 - 1964
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-4-thioxo-3,4-dihydropyrimidin-2(1H)-one structure

1-((2R,3R,4S,5R...

CAS#:933444-01-0

~%

5'-Deoxy-5-fluorocytidine Structure

5'-Deoxy-5-fluo...

CAS#:66335-38-4

Literature: Chinese Chemical Letters, , vol. 21, # 2 p. 163 - 166
N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]-3,4,5-trimethoxybenzamide structure

N-[1-[(2R,3R,4S...

CAS#:124012-42-6

~%

3,4,5-TRIMETHOXYBENZAMIDE structure

3,4,5-TRIMETHOX...

CAS#:3086-62-2

5'-Deoxy-5-fluorocytidine Structure

5'-Deoxy-5-fluo...

CAS#:66335-38-4

Trimethylgallic acid structure

Trimethylgallic acid

CAS#:118-41-2

Detail
Literature: Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2568 - 2571

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5'-deoxy-5-fluoro-Cytidine
5'-Deoxy-5-fluorocytidine
MFCD07369278
Cytidine, 5'-deoxy-5-fluoro-
4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydro-2-furanyl]-5-fluoro-2(1H)-pyrimidinone
5'-Deoxy-5-fluoro Cytidine
Capecitabine Impurity 1
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Chemsrc provides 5'-Deoxy-5-fluorocytidine(CAS#:66335-38-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 5'-Deoxy-5-fluorocytidine are included as well.>> amp version: 5'-Deoxy-5-fluorocytidine

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