Protectin D1

Modify Date: 2025-08-25 12:58:56

Protectin D1 Structure
Protectin D1 structure
Common Name Protectin D1
CAS Number 660430-03-5 Molecular Weight 360.48700
Density N/A Boiling Point N/A
Molecular Formula C22H32O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Protectin D1


Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models[1][2].

 Names

Name protectin D1
Synonym More Synonyms

 Protectin D1 Biological Activity

Description Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models[1][2].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823.

[2]. Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859.

 Chemical & Physical Properties

Molecular Formula C22H32O4
Molecular Weight 360.48700
Exact Mass 360.23000
PSA 77.76000
LogP 4.49050
InChIKey CRDZYJSQHCXHEG-SFVBTVKNSA-N
SMILES CCC=CCC(O)C=CC=CC=CC(O)CC=CCC=CCCC(=O)O

 Protectin D1Bioassay

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Name: Drug excretion in healthy human urine assessed as 3Z,6R,7E,9E,11Z,13S,15Z)-6,13-Dihyd...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4416598
Name: Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3383285
Name: Inhibition of LTB4-induced chemotaxis in human polymorphonuclear leukocytes incubated...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4416599
Name: Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3383287
Name: Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3383286
Name: Inhibition of LTB4-induced chemotaxis of human primary PMN at 0.01 to 100 nM pre-incu...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3383289
Name: Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3383288
Name: Antiinflammatory activity in mouse assessed as reduction of zymosan-induced neutrophi...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3241216
Name: Inhibition of LTB4-induced cell adhesion to fibronectin in human primary PMN at 0.1 t...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3383291
Name: Antiinflammatory activity in mouse assessed as reduction of zymosan-induced number of...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3242311
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 Synonyms

(4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxy-4,7,11,13,15,19-docosahexaenoic acid
10R,17S-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
NPD1
PD1
neuroprotectin D1
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