Protectin D1

Names

[ Name ]:
Protectin D1

[Synonym ]:
(4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxy-4,7,11,13,15,19-docosahexaenoic acid
10R,17S-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
NPD1
PD1
neuroprotectin D1

Biological Activity

[Description]:

Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823.

[2]. Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₂O₄

[ Molecular Weight ]:
360.48700

[ Exact Mass ]:
360.23000

[ PSA ]:
77.76000

[ LogP ]:
4.49050

Related Compounds

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