Protectin D1

• 常用名: Protectin D1
• 英文名: Protectin D1
• CAS号: 660430-03-5
• 分子量: 360.48700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₃₂O₄
• 熔点: N/A
• 闪点: N/A

Protectin D1用途

保护蛋白D1是由神经细胞产生的神经保护蛋白D1,是由二十二碳六烯酸产生的一个新的生物活性产物家族的成员。Protectin D1也是一种特殊的促分解介质,在几种人类疾病模型体内具有强大的促分解和抗炎作用[1][2]。

Protectin D1名称

• 英文名: protectin D1

Protectin D1生物活性

• 描述: 保护蛋白D1是由神经细胞产生的神经保护蛋白D1,是由二十二碳六烯酸产生的一个新的生物活性产物家族的成员。Protectin D1也是一种特殊的促分解介质,在几种人类疾病模型体内具有强大的促分解和抗炎作用[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
• 靶点实验:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823.

  [2]. Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859.

Protectin D1物理化学性质

• 分子式: C₂₂H₃₂O₄
• 分子量: 360.48700
• 精确质量: 360.23000
• PSA: 77.76000
• LogP: 4.49050
• InChIKey: CRDZYJSQHCXHEG-SFVBTVKNSA-N
• SMILES: CCC=CCC(O)C=CC=CC=CC(O)CC=CCC=CCCC(=O)O

Protectin D1靶点实验

查看更多实验

实验名称：Drug excretion in healthy human urine assessed as 3Z,6R,7E,9E,11Z,13S,15Z)-6,13-Dihyd... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4416598

实验名称：Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3383285

实验名称：Inhibition of LTB4-induced chemotaxis in human polymorphonuclear leukocytes incubated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4416599

实验名称：Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3383287

实验名称：Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3383286

实验名称：Inhibition of LTB4-induced chemotaxis of human primary PMN at 0.01 to 100 nM pre-incu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3383289

实验名称：Anti-inflammatory activity in FVB mouse with zymosan-induced sterile peritonitis asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3383288

实验名称：Antiinflammatory activity in mouse assessed as reduction of zymosan-induced neutrophi... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3241216

实验名称：Inhibition of LTB4-induced cell adhesion to fibronectin in human primary PMN at 0.1 t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3383291

实验名称：Antiinflammatory activity in mouse assessed as reduction of zymosan-induced number of... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3242311

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Protectin D1英文别名

• (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxy-4,7,11,13,15,19-docosahexaenoic acid
• 10R,17S-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
• 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
• NPD1
• PD1
• neuroprotectin D1