HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416598

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drugexcretion	Metabolite_Notdetected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3383285

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	54	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416599

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Units	Activity Comment
Inhibition	%	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3383287

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3383286

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3383289

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3383288

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3241216

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 4
First Page: 910
Last Page: 916
DOI: 10.1021/np4009865

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3383291

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3242311

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 4
First Page: 910
Last Page: 916
DOI: 10.1021/np4009865

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3383290

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 10
First Page: 2241
Last Page: 2247
DOI: 10.1021/np500498j

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macrophage

External ID: CHEMBL3241218

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2014
Volume: 77
Issue: 4
First Page: 910
Last Page: 916
DOI: 10.1021/np4009865

Target ChEMBL ID: CHEMBL612578
ChEMBL Target Name: Macrophage
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416590

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	4	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macrophage

External ID: CHEMBL3241217

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2014
Volume: 77
Issue: 4
First Page: 910
Last Page: 916
DOI: 10.1021/np4009865

Target ChEMBL ID: CHEMBL612578
ChEMBL Target Name: Macrophage
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416591

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416592

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416595

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
Drug recovery	=	105.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416596

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drugexcretion	Metabolite_Detected
Drugexcretion	Metabolite_Notdetected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416597

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drugexcretion	Metabolite_Notdetected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416582

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416583

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
Drug metabolism	=	9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416585

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
Drug metabolism	>	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416586

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	>	4	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416587

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	1	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416588

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	0.5	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416589

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	4	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416574

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416575

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416576

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Activity Comment
Drug uptake	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416577

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416578

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416579

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Relation	Standard Value	Standard Units
Stability	=	0	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416580

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416581

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Notdetected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416569

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416570

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416571

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4416573

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 21
First Page: 9961
Last Page: 9975
DOI: 10.1021/acs.jmedchem.9b01463

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

660430-03-5 靶点实验数据