Psoralen

Modify Date: 2024-01-02 08:28:29

Psoralen structure	Common Name	Psoralen
	CAS Number	66-97-7	Molecular Weight	186.163
	Density	1.4±0.1 g/cm3	Boiling Point	362.6±27.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₆O₃	Melting Point	160-162 °C
	MSDS	Chinese USA	Flash Point	173.1±23.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Psoralen

Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3].

Name	psoralen
Synonym	More Synonyms

Description	Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Phenylpropanoids
References	[1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6. [2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7. [3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Natural Products >> Phenylpropanoids

References

[1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6.

[2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7.

[3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10.

Density	1.4±0.1 g/cm3
Boiling Point	362.6±27.0 °C at 760 mmHg
Melting Point	160-162 °C
Molecular Formula	C₁₁H₆O₃
Molecular Weight	186.163
Flash Point	173.1±23.7 °C
Exact Mass	186.031693
PSA	43.35000
LogP	1.67
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.667
Storage condition	2-8°C

Psoralen MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV0944000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one

CAS REGISTRY NUMBER :: 66-97-7

BEILSTEIN REFERENCE NO. :: 0152784

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H6-O3

MOLECULAR WEIGHT :: 186.17

WISWESSER LINE NOTATION :: T C566 DO LVOJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 50 umol/L

REFERENCE :: BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1966- Volume(issue)/page/year: 67,245,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LV0944000

Precursor 9
CAS#:849144-95-2 xanthoarnol CAS#:6544-89-4 3,4-dihydropsoralen CAS#:7535-48-0 4',5'-dihydrops... CAS#:16851-02-8 2-(2-oxochromen...
CAS#:52656-95-8 7-oxo-2,3-dihyd... CAS#:15085-71-9 Micromelin CAS#:287171-02-2 (+)-(2'S,3'R)-3... CAS#:13196-11-7 1-Benzofuran-6-ol
CAS#:623-47-2 Ethyl propiolate
DownStream 4
CAS#:20073-22-7 5-Benzofurancar... CAS#:6544-89-4 3,4-dihydropsoralen CAS#:7535-48-0 4',5'-dihydrops... CAS#:19881-52-8 tetrahydropsoralen

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Furocoumarin

7H-Furo[3,2-g]chromen-7-one

Psoralen

EINECS 200-639-7

Psoralene

prosuler

6,7-Furanocoumarin

MFCD00010520

Psorline-P

FICUSIN

7H-Furo[3,2-g][1]benzopyran-7-one

BioBioPha
China
Product Name: Psoralen
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Psoralen
Price: ￥178.0/20mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Psoralen
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥312/25mg

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Psoralen

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