1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Modify Date: 2024-01-09 18:44:38

1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure
1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione structure
 Common Name 1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
CAS Number 6554-11-6 Molecular Weight 728.83
Density 1.33g/cm3 Boiling Point N/A
Molecular Formula C47H40N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione


2',5'-Bis-O-(triphenylMethyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents[1].

 Names

Name Enzastaurin hcl
Synonym More Synonyms

  Biological Activity

Description 2',5'-Bis-O-(triphenylMethyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents[1].
Related Catalog
References

[1]. Connolly GP, et al. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999 May;20(5):218-25.  

 Chemical & Physical Properties

Density 1.33g/cm3
Molecular Formula C47H40N2O6
Molecular Weight 728.83
Exact Mass 728.28900
PSA 102.78000
LogP 7.18090
Index of Refraction 1.705

 Synthetic Route

Triphenylmethyl Chloride structure

Triphenylmethyl...

CAS#:76-83-5
Uridine structure

Uridine

CAS#:58-96-8

~16%

5'-o-trityluridine structure

5'-o-trityluridine

CAS#:6554-10-5
3′,5′-Bis-O-(triphenylmethyl)uridine structure

3′,5′-Bis-O-(tr...

CAS#:4710-75-2
Detail
Literature: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255
Triphenylmethyl Chloride structure

Triphenylmethyl...

CAS#:76-83-5
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]pyrimidine-2,4-dione structure

1-[(2R,3R,4S,5R...

CAS#:51600-12-5

~%

3′,5′-Bis-O-(triphenylmethyl)uridine structure

3′,5′-Bis-O-(tr...

CAS#:4710-75-2
1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[4-hydroxy-3-...

CAS#:6554-11-6
Literature: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255
Triphenylmethyl Chloride structure

Triphenylmethyl...

CAS#:76-83-5
Uridine structure

Uridine

CAS#:58-96-8

~31%

5'-o-trityluridine structure

5'-o-trityluridine

CAS#:6554-10-5
N/A structure

N/A

CAS#:13964-43-7
Detail
Literature: Rhie; Pfleiderer Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
Triphenylmethyl Chloride structure

Triphenylmethyl...

CAS#:76-83-5
Uridine structure

Uridine

CAS#:58-96-8

~68%

1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[4-hydroxy-3-...

CAS#:6554-11-6
Literature: Pierra, Claire; Amador, Agnes; Badaroux, Eric; Storer, Richard; Gosselin, Gilles Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 991 - 1010
Triphenylmethyl Chloride structure

Triphenylmethyl...

CAS#:76-83-5
5'-o-trityluridine structure

5'-o-trityluridine

CAS#:6554-10-5

~42%

3′,5′-Bis-O-(triphenylmethyl)uridine structure

3′,5′-Bis-O-(tr...

CAS#:4710-75-2
1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[4-hydroxy-3-...

CAS#:6554-11-6
Literature: Rhie; Pfleiderer Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
Triphenylmethyl Chloride structure

Triphenylmethyl...

CAS#:76-83-5
Uridine structure

Uridine

CAS#:58-96-8

~38%

3′,5′-Bis-O-(triphenylmethyl)uridine structure

3′,5′-Bis-O-(tr...

CAS#:4710-75-2
1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[4-hydroxy-3-...

CAS#:6554-11-6
Literature: Auguste, Sandra P.; Young, Douglas W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 395 - 404
4-Methoxytriphenylmethyl chloride structure

4-Methoxytriphe...

CAS#:14470-28-1

~%

1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[4-hydroxy-3-...

CAS#:6554-11-6
Literature: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255
Uridine structure

Uridine

CAS#:58-96-8

~%

1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[4-hydroxy-3-...

CAS#:6554-11-6
Literature: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255

 Synonyms

2',5'-Di-O-trityl-uridin
2',5'-bis-O-trityluridine
Enzastaurin Hydrochloride
2',5'-Bis-triphenylmethyl-pyrimidin-ribosid
2',5'-di-O-trityluridine
2',5'-ditrityluridine
O2',O5'-ditrityl-uridine
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Chemsrc provides CAS#:6554-11-6 MSDS, density, melting point, boiling point, structure, etc. Its name is 1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione>> amp version: 1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

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