In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

…, M Saudi, J Rozenski, J Neyts, A Van Aerschot

Index: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255

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Citation Number: 12

Abstract

Abstract Following up on a hit that was identified in a large scale cell-based antiviral screening effort, a series of triphenylmethyl alkylated nucleoside analogues were synthesized and evaluated for their in vitro antiviral activities against the dengue virus (DENV) and the yellow fever virus (YFV). Hereto, trityl moieties were attached at various positions of the sugar ring combined with subtle variations of the heterocyclic base. ...