12,14-Dichlorodehydroabietic acid

Modify Date: 2024-01-11 20:01:53

12,14-Dichlorodehydroabietic acid structure	Common Name	12,14-Dichlorodehydroabietic acid
	CAS Number	65281-77-8	Molecular Weight	369.32500
	Density	1.2g/cm3	Boiling Point	469.6ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₆Cl₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	237.8ºC

Use of 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].

Name	(1R,4aS,10aR)-6,8-dichloro-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid
Synonym	More Synonyms

Description	12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	Ca2+-activated K+ (BK) channel[2] GABAA[1]
References	[1]. R A Nicholson, et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. Br J Pharmacol. 1999 Mar;126(5):1123-32. [2]. Kazuho Sakamoto, et al. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther. 2006 Jan;316(1):144-53.

Density	1.2g/cm3
Boiling Point	469.6ºC at 760 mmHg
Molecular Formula	C₂₀H₂₆Cl₂O₂
Molecular Weight	369.32500
Flash Point	237.8ºC
Exact Mass	368.13100
PSA	37.30000
LogP	6.21170
Index of Refraction	1.555