Dimethyl Glutamate

Modify Date: 2024-01-10 13:26:23

Dimethyl Glutamate structure	Common Name	Dimethyl Glutamate
	CAS Number	6525-53-7	Molecular Weight	175.18200
	Density	1.129 g/cm3	Boiling Point	224.292ºC at 760 mmHg
	Molecular Formula	C₇H₁₃NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	76.674ºC

Use of Dimethyl Glutamate

Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism[1][2][3][4].

Name	(S)-Dimethyl 2-aminopentanedioate
Synonym	More Synonyms

Description	Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism[1][2][3][4].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Anti-infection >> Bacterial
Target	KATP channel[4]
References	[1]. J Cancelas, et al. Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. Int J Mol Med. 2001 Nov;8(5):531-2. [2]. Sener A, et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology-Endocrinology and Metabolism, 1994, 267(4): E573-E584. [3]. I S Owens, et al. Induction of abnormal cell division in Euglena gracilis by glutamic diethyl ester. J Protozool. 1969 May;16(2):211-5. [4]. Hidenori Katsuta, et al. Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN 6 beta cells. Biochem Biophys Res Commun. 2003 Nov 21;311(3):660-4.

Density	1.129 g/cm3
Boiling Point	224.292ºC at 760 mmHg
Molecular Formula	C₇H₁₃NO₄
Molecular Weight	175.18200
Flash Point	76.674ºC
Exact Mass	175.08400
PSA	78.62000
LogP	0.14020

Hazard Codes	Xi

Precursor 9
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CAS#:186581-53-3 diazomethane
DownStream 9
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