Dimethyl Glutamate

Names

[ Name ]:
Dimethyl Glutamate

[Synonym ]:
dimethyl L-glutamate
L-glutamic acid a,g-dimethyl ester
glutamic acid dimethyl ester
L-glutamic acid dimethyl ester
Dimethyl Glutamate
Einecs 229-414-1

Biological Activity

[Description]:

Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism[1][2][3][4].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

KATP channel[4]

[References]

[1]. J Cancelas, et al. Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. Int J Mol Med. 2001 Nov;8(5):531-2.

[2]. Sener A, et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology-Endocrinology and Metabolism, 1994, 267(4): E573-E584.

[3]. I S Owens, et al. Induction of abnormal cell division in Euglena gracilis by glutamic diethyl ester. J Protozool. 1969 May;16(2):211-5.

[4]. Hidenori Katsuta, et al. Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN 6 beta cells. Biochem Biophys Res Commun. 2003 Nov 21;311(3):660-4.

Chemical & Physical Properties

[ Density]:
1.129 g/cm3

[ Boiling Point ]:
224.292ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₁₃NO₄

[ Molecular Weight ]:
175.18200

[ Flash Point ]:
76.674ºC

[ Exact Mass ]:
175.08400

[ PSA ]:
78.62000

[ LogP ]:
0.14020

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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