Z-Phe-Arg-AMC · HCl

Modify Date: 2024-01-07 16:00:46

Z-Phe-Arg-AMC · HCl structure	Common Name	Z-Phe-Arg-AMC · HCl
	CAS Number	65147-22-0	Molecular Weight	612.68
	Density	1.32 g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₃H₃₆N₆O₆	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Z-Phe-Arg-AMC · HCl

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].

Name	Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride
Synonym	More Synonyms

Description	N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53. [2]. Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94.

Description

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53.

[2]. Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94.

Density	1.32 g/cm3
Molecular Formula	C₃₃H₃₆N₆O₆
Molecular Weight	612.68
Exact Mass	648.24600
PSA	188.64000
LogP	6.17340
Index of Refraction	1.639
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.

Meth. Enzymol. 80 , 341, (1981)

Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.

PLoS ONE 8(1) , e54187, (2013)

Drosophila melanogaster crammer is a novel cathepsin inhibitor involved in long-term memory formation. A molten globule-to-ordered structure transition is required for cathepsin inhibition. This study...

Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC.

Immunopharmacology 36(2-3) , 295-303, (1997)

Anti-peptide antibodies were produced against the cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei and the effects of these antibodies on enzyme activity against carboxybenzoyl (Z)-Ph...

benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate

MFCD00077030

Zhejiang Hangyu API Co., Ltd
China
Product Name: Z-Phe-Arg-AMC
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Purity: 99.0%
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