Z-Phe-Arg-AMC · HCl

Names

[ Name ]:
Z-Phe-Arg-AMC · HCl

[Synonym ]:
benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
MFCD00077030

Biological Activity

[Description]:

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53.

[2]. Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94.

Chemical & Physical Properties

[ Density]:
1.32 g/cm3

[ Molecular Formula ]:
C₃₃H₃₆N₆O₆

[ Molecular Weight ]:
612.68

[ Exact Mass ]:
648.24600

[ PSA ]:
188.64000

[ LogP ]:
6.17340

[ Index of Refraction ]:
1.639

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.

Meth. Enzymol. 80 , 341, (1981)

Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.

PLoS ONE 8(1) , e54187, (2013)

Drosophila melanogaster crammer is a novel cathepsin inhibitor involved in long-term memory formation. A molten globule-to-ordered structure transition is required for cathepsin inhibition. This study...

Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC.

Immunopharmacology 36(2-3) , 295-303, (1997)

Anti-peptide antibodies were produced against the cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei and the effects of these antibodies on enzyme activity against carboxybenzoyl (Z)-Ph...