Nanchangmycin

Modify Date: 2025-08-26 17:38:41

Nanchangmycin Structure
Nanchangmycin structure
Common Name Nanchangmycin
CAS Number 65101-87-3 Molecular Weight 889.10
Density N/A Boiling Point N/A
Molecular Formula C47H77NaO14 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nanchangmycin


Nanchangmycin, produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

 Names

Name Dianemycin, monosodium salt
Synonym More Synonyms

 Nanchangmycin Biological Activity

Description Nanchangmycin, produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
Related Catalog
Target

Bacteria[1] Zika virus[2]

In Vitro Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria[1]. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types[2].
References

[1]. Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58.

[2]. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.

 Chemical & Physical Properties

Molecular Formula C47H77NaO14
Molecular Weight 889.10
PSA 188.90000
LogP 6.14960
InChIKey XMAIRYYXDCNFKP-DYTQFKGPSA-M
SMILES COC1CCC(OC2CC(C3(C)CCC4(CC(O)C(C)C(C(C)C=C(C)C(=O)C(C)CC(C)C(=O)[O-])O4)O3)OC3(OC(C4OC(O)(CO)C(C)CC4C)CC3C)C2C)OC1C.[Na+]
Storage condition -20℃

 Synonyms

Nanchangmycin
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