65101-87-3

65101-87-3 structure

Name: Nanchangmycin
Chemical Name: Dianemycin, monosodium salt
CAS Number: 65101-87-3
Molecular Formula: C₄₇H₇₇NaO₁₄
Molecular Weight: 889.10
Catalog: API Antibiotics Agricultural antibiotics
Create Date: 2017-08-20 04:32:34
Modify Date: 2024-01-16 11:27:32
Nanchangmycin, produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

Name	Dianemycin, monosodium salt
Synonyms	Nanchangmycin

Description	Nanchangmycin, produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Others
Target	Bacteria[1] Zika virus[2]
In Vitro	Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria[1]. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types[2].
References	[1]. Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58. [2]. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.