Captopril disulfide
Captopril disulfide structure
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Common Name | Captopril disulfide | ||
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| CAS Number | 64806-05-9 | Molecular Weight | 432.55500 | |
| Density | 1.383g/cm3 | Boiling Point | 714.796ºC at 760 mmHg | |
| Molecular Formula | C18H28N2O6S2 | Melting Point | 224-226ºC | |
| MSDS | Chinese USA | Flash Point | 386.095ºC | |
Use of Captopril disulfideCaptopril disulfide is a metabolite of Captopril with antihypertensive activity[1]. |
| Name | captopril disulfide |
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| Synonym | More Synonyms |
| Description | Captopril disulfide is a metabolite of Captopril with antihypertensive activity[1]. |
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| Related Catalog | |
| References |
| Density | 1.383g/cm3 |
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| Boiling Point | 714.796ºC at 760 mmHg |
| Melting Point | 224-226ºC |
| Molecular Formula | C18H28N2O6S2 |
| Molecular Weight | 432.55500 |
| Flash Point | 386.095ºC |
| Exact Mass | 432.13900 |
| PSA | 165.82000 |
| LogP | 1.66700 |
| Index of Refraction | 1.6 |
| Storage condition | -20?C Freezer |
| RIDADR | NONH for all modes of transport |
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Captopril disulfide CAS#:64806-05-9 |
| Literature: Pharmazie, , vol. 63, # 12 p. 872 - 877 |
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Captopril disulfide CAS#:64806-05-9 |
| Literature: Journal of Pharmaceutical Sciences, , vol. 88, # 10 p. 981 - 986 |
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Captopril disulfide CAS#:64806-05-9 |
| Literature: Bioorganic Chemistry, , vol. 23, # 2 p. 109 - 118 |
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Captopril disulfide CAS#:64806-05-9 |
| Literature: Canadian Journal of Chemistry, , vol. 76, # 6 p. 789 - 794 |
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Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat.
Biochem. Pharmacol. 33(22) , 3567-71, (1984) The absorption and metabolism of the disulfide dimer conjugate of captopril has been studied in the rat following both oral and intravenous dosing and compared with that of the active monomer, captopr... |
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The pharmacokinetics of captopril and captopril disulfide conjugates in uraemic patients on maintenance dialysis: comparison with patients with normal renal function.
Eur. J. Clin. Pharmacol. 32(3) , 267-71, (1987) We have measured the plasma concentrations of captopril and total disulfide conjugates of captopril after a 50 mg oral dose in 6 uraemic patients on maintenance dialysis and in 8 hypertensive subjects... |
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[Determination of captopril plus its disulfide metabolites in human plasma].
Yao Xue Xue Bao 33(8) , 605-9, (1998) A new and sensitive HPLC method has been developed for the determination of captopril plus its disulfide metabolites (total captopril) in human plasma. Captopril disulfides and the drug covalently bou... |
| Captopril Disulfide |
| 1,1'-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline |
| CAPTOPRIL DISULFIDE |
| Captopril Impurity 1 |