Tetrahydroalstonine

Modify Date: 2024-01-04 14:06:50

Tetrahydroalstonine structure	Common Name	Tetrahydroalstonine
	CAS Number	6474-90-4	Molecular Weight	352.427
	Density	1.3±0.1 g/cm3	Boiling Point	524.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₄N₂O₃	Melting Point	227ºC
	MSDS	N/A	Flash Point	270.7±30.1 °C

Use of Tetrahydroalstonine

Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].

Name	Alstonine, 3,4,5,6-tetrahydro-, (3.α.)
Synonym	More Synonyms

Description	Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Malik S, et al. Tetrahydroalstonine from Fruits of Rhazya stricta. Planta Med. 1984 Jun;50(3):283. [2]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5.https://www.ncbi.nlm.nih.gov/pubmed/6099269

Description

Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].

Related Catalog

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

References

CHEMICAL NAME :: Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19-alpha,20-alpha)-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3969521

Precursor 8
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