Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tetrahydroalstonine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tetrahydroalstonine
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6474-90-4

6474-90-4 structure

6474-90-4 structure

Name: Tetrahydroalstonine
Chemical Name: Alstonine, 3,4,5,6-tetrahydro-, (3.α.)
CAS Number: 6474-90-4
Molecular Formula: C₂₁H₂₄N₂O₃
Molecular Weight: 352.427
Catalog: Natural product Alkaloid
Create Date: 2018-09-29 12:00:34
Modify Date: 2025-08-25 18:39:47
Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].

Name	Alstonine, 3,4,5,6-tetrahydro-, (3.α.)
Synonyms	oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester 8-Methyl-5,6,7a,8,11a,12,12a,13-octahydro-7H-9-oxa-6a,13-diaza-indeno[2,1-a]anthracene-11-carboxylic acid methyl ester 3S,15S,19S,20S-tetrahydroalstonine ALSTONINE Methyl (3ξ,19α,20α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate Tetrahydroalstonine 3,4,5,6-tetrahydro-alstonin Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (3ξ,19α,20α)- methyl 19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate

Description	Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Malik S, et al. Tetrahydroalstonine from Fruits of Rhazya stricta. Planta Med. 1984 Jun;50(3):283. [2]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5.https://www.ncbi.nlm.nih.gov/pubmed/6099269

Density	1.3±0.1 g/cm3
Boiling Point	524.0±50.0 °C at 760 mmHg
Melting Point	227ºC
Molecular Formula	C₂₁H₂₄N₂O₃
Molecular Weight	352.427
Flash Point	270.7±30.1 °C
Exact Mass	352.178680
PSA	54.56000
LogP	2.88
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.656
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP5776600

CHEMICAL NAME :: Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19-alpha,20-alpha)-

CAS REGISTRY NUMBER :: 6474-90-4

BEILSTEIN REFERENCE NO. :: 0097270

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H24-N2-O3

MOLECULAR WEIGHT :: 352.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3969521

Precursor 8
19456-89-4 63661-74-5 61-54-1 67-68-5
83541-47-3 19351-63-4 73385-57-6 51020-37-2
DownStream 0

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