6474-90-4

6474-90-4 structure

Name: Tetrahydroalstonine
Chemical Name: Alstonine, 3,4,5,6-tetrahydro-, (3.α.)
CAS Number: 6474-90-4
Molecular Formula: C₂₁H₂₄N₂O₃
Molecular Weight: 352.427
Catalog: Natural product Alkaloid
Create Date: 2018-09-29 12:00:34
Modify Date: 2024-01-04 14:06:50
Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].

Name	Alstonine, 3,4,5,6-tetrahydro-, (3.α.)
Synonyms	oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester 8-Methyl-5,6,7a,8,11a,12,12a,13-octahydro-7H-9-oxa-6a,13-diaza-indeno[2,1-a]anthracene-11-carboxylic acid methyl ester 3S,15S,19S,20S-tetrahydroalstonine ALSTONINE Methyl (3ξ,19α,20α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate Tetrahydroalstonine 3,4,5,6-tetrahydro-alstonin Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (3ξ,19α,20α)- methyl 19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate

Description	Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Malik S, et al. Tetrahydroalstonine from Fruits of Rhazya stricta. Planta Med. 1984 Jun;50(3):283. [2]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5.https://www.ncbi.nlm.nih.gov/pubmed/6099269