Aminotrimethylene phosphonic acid

Modify Date: 2025-08-21 16:17:31

Aminotrimethylene phosphonic acid Structure
Aminotrimethylene phosphonic acid structure
Common Name Aminotrimethylene phosphonic acid
CAS Number 6419-19-8 Molecular Weight 299.050
Density 2.1±0.1 g/cm3 Boiling Point 746.2±70.0 °C at 760 mmHg
Molecular Formula C3H12NO9P3 Melting Point ~215 °C (dec.)
MSDS Chinese USA Flash Point 405.1±35.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name Amino tris(methylene phosphonic acid)
Synonym More Synonyms

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 746.2±70.0 °C at 760 mmHg
Melting Point ~215 °C (dec.)
Molecular Formula C3H12NO9P3
Molecular Weight 299.050
Flash Point 405.1±35.7 °C
Exact Mass 298.972504
PSA 205.26000
LogP -4.63
Vapour Pressure 0.0±5.4 mmHg at 25°C
Index of Refraction 1.610
Stability Stable. Incompatible with bases, strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ9860000
CHEMICAL NAME :
Phosphonic acid, (nitrilotris(methylene))tri-
CAS REGISTRY NUMBER :
6419-19-8
BEILSTEIN REFERENCE NO. :
1715724
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C3-H12-N-O9-P3
MOLECULAR WEIGHT :
299.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),67,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>6310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>2510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
>2510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1302 mg/kg/31D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),67,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1717 No. of Facilities: 72 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1279 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1717 No. of Facilities: 2426 (estimated) No. of Industries: 57 No. of Occupations: 33 No. of Employees: 38609 (estimated) No. of Female Employees: 2280 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes C:Corrosive
Risk Phrases R34
Safety Phrases S26-S45-S36/37/39-S25
RIDADR 3265
WGK Germany 1
RTECS SZ9860000
Packaging Group III
Hazard Class 8
HS Code 2931900090

 Synthetic Route

~69%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: STRAITMARK HOLDING AG; NOTTE, Patrick; PIRARD, Cedric, Nicolas; LEMIN, David Patent: WO2010/136573 A1, 2010 ; Location in patent: Page/Page column 18 ;

~98%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: STRAITMARK HOLDING AG; NOTTÉ, Patrick; COGELS, Samuel; BURCK, Sebastian Patent: WO2014/12990 A1, 2014 ; Location in patent: Page/Page column 18; 27; 28; 30 ;

~%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: EP2112156 A1, ; Page/Page column 10 ;

~8%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Detail
Literature: Arkivoc, , vol. 2010, # 11 p. 360 - 369

~%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: Zhurnal Obshchei Khimii, , vol. 29, p. 591,592, 593; engl. Ausg. S. 587

~8%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: WO2014/12990 A1, ; Page/Page column 27 ;

~%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: Liebigs Annalen der Chemie, , # 11 p. 1153 - 1155

~%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Literature: Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 33, # 12 p. 2535 - 2540 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 12 p. 2768 - 2773

~%

Aminotrimethylene phosphonic acid Structure

Aminotrimethyle...

CAS#:6419-19-8

Detail
Literature: Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 33, # 12 p. 2535 - 2540 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 12 p. 2768 - 2773

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 Articles14

More Articles
Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.

Proc. Natl. Acad. Sci. U. S. A. 104 , 12282-7, (2007)

Conjugative transfer of plasmid DNA via close cell-cell junctions is the main route by which antibiotic resistance genes spread between bacterial strains. Relaxases are essential for conjugative trans...

Determination of phosphonates in natural waters by ion-pair high-performance liquid chromatography.

J. Chromatogr. A. 773(1-2) , 139-46, (1997)

The paper describes a new method for the determination of phosphonates by ion-pair high-performance liquid chromatography. The phosphonates are complexed with Fe(III) and separated on a reversed-phase...

Adsorptive removal of nitrilotris(methylenephosphonic acid) antiscalant from membrane concentrates by iron-coated waste filtration sand.

J. Hazard. Mater. 182(1-3) , 855-62, (2010)

Iron-coated waste filtration sand was investigated as a low-cost adsorbent for the removal of nitrilotris(methylenephosphonic acid) (NTMP) from membrane concentrates. The adsorption of this phosphonat...

 Synonyms

Aminotri(methylene phosphonic acid)
nitrilotrimethylenephosphonic acid
N,N,N-triphosphonomethyl amine
Aminotris(methylphosphonic acid)
[Nitrilotris(methylene)]tris(phosphonic acid)
N_Tf
(Nitrilotris(methylene))triphosphonic acid
ATMP
ferrofos509
ATMPA
(nitrilotrimethanediyl)tris(phosphonic acid)
UNII-1Y702GD0FG
dowelll37
ntpo
Dequest 2000
BRIQUEST 301-50A
Aminotris(methanephosphonic acid)
Briquest 301
EINECS 229-146-5
MFCD00002138
Amino tris(methylene phosphonic acid)
Phosphonic acid, [nitrilotris(methylene)]tris-
Amino tris (methylene phosphonic acid)
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