Sedanolide

Modify Date: 2025-08-20 12:50:12

Use of Sedanolide

Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities[1][2].

Name	3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one
Synonym	More Synonyms

Description	Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities[1][2].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
In Vitro	Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells[2].
In Vivo	Sedanolide increases the activity of glutathione-S-transferase (GST) in the liver, small intestinal mucosa, and forestomach of A/J mice[1].
References	[1]. J A Woods， et al. Sedanolide, a Natural Phthalide From Celery Seed Oil: Effect on Hydrogen Peroxide and Tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 and CaCo-2 Human Cell Lines. In Vitr Mol Toxicol. Fall 2001;14(3):233-40. [2]. Shu-Ling Hsieh, et al. Sedanolide Induces Autophagy Through the PI3K, p53 and NF-κB Signaling Pathways in Human Liver Cancer Cells. Int J Oncol. 2015 Dec;47(6):2240-6.

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36

Neocnidilide

3-butyl-3a,4,5,6-tetrahydro-3H-isobenzofuran-1-one

Sedanolide

MFCD00171327

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