Akuammidine

Modify Date: 2024-01-02 23:55:04

Akuammidine Structure
Akuammidine structure
Common Name Akuammidine
CAS Number 639-36-1 Molecular Weight 352.427
Density 1.3±0.1 g/cm3 Boiling Point 513.0±50.0 °C at 760 mmHg
Molecular Formula C21H24N2O3 Melting Point 243-246℃
MSDS N/A Flash Point 264.0±30.1 °C

 Use of Akuammidine


Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].

 Names

Name Akuammidine
Synonym More Synonyms

 Akuammidine Biological Activity

Description Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].
Related Catalog
In Vitro Akuammidine treatment decreases the expression of IL-6 in cells[1][2].
References

[1]. Yuanyuan Hou, et al. Microfractionation Bioactivity-Based Ultra Performance Liquid Chromatography/Quadrupole Time-Of-Flight Mass Spectrometry for the Identification of Nuclear factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in an Alkaloidal Extract of the Folk Herb Alstonia Scholaris. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104.

[2]. J R Menzies, et al. Opioid Activity of Alkaloids Extracted From Picralima Nitida (Fam. Apocynaceae). Eur J Pharmacol. 1998 May 29;350(1):101-8.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 513.0±50.0 °C at 760 mmHg
Melting Point 243-246℃
Molecular Formula C21H24N2O3
Molecular Weight 352.427
Flash Point 264.0±30.1 °C
Exact Mass 352.178680
PSA 65.56000
LogP 2.99
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.683

 Safety Information

Hazard Codes Xi

 Synonyms

Methyl (15α,19E)-17-hydroxysarpagan-16-carboxylate
Sarpagan-16-carboxylic acid, 17-hydroxy-, methyl ester, (15α)-
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Akuammidine
  • Price: ¥3750.0/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

  • DC Chemicals Limited
  • China
  • Product Name: Akuammidine
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
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