(S)-Baclofen hydrochloride

Modify Date: 2024-01-06 13:42:40

(S)-Baclofen hydrochloride Structure
(S)-Baclofen hydrochloride structure
Common Name (S)-Baclofen hydrochloride
CAS Number 63701-56-4 Molecular Weight 250.12200
Density N/A Boiling Point 364.3ºC at 760mmHg
Molecular Formula C10H13Cl2NO2 Melting Point 223 - 224 °C
MSDS USA Flash Point 174.1ºC

 Names

Name (3S)-4-amino-3-(4-chlorophenyl)butanoic acid,hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 364.3ºC at 760mmHg
Melting Point 223 - 224 °C
Molecular Formula C10H13Cl2NO2
Molecular Weight 250.12200
Flash Point 174.1ºC
Exact Mass 249.03200
PSA 63.32000
LogP 3.35930

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MW5084400
CHEMICAL NAME :
Hydrocinnamic acid, beta-(aminomethyl)-p-chloro-, hydrochloride, (S)-
CAS REGISTRY NUMBER :
63701-56-4
LAST UPDATED :
198503
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H12-Cl-N-O2.Cl-H
MOLECULAR WEIGHT :
250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,187,1980

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR UN 2811 6.1/PG 3
RTECS MW5084400

 Synthetic Route

 Articles4

More Articles
Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.

Eur. J. Pharmacol. 196 , 267, (1991)

In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the pre...

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.

J. Neurochem. 47 , 898, (1986)

The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)-...

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

Pol. J. Pharmacol. Pharm. 32 , 187, (1980)

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enanti...

 Synonyms

UNII-799SU69U5P
S(-)-Baclofen hydrochloride
(-)-Baclofen hydrochloride
l-Baclofen hydrochloride
(-)-S-3-(p-Chlorophenyl)-4-aminobutanoic acid hydrochloride
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