1,4-Anthracenedione
Modify Date: 2024-01-08 19:32:14
1,4-Anthracenedione structure
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Common Name | 1,4-Anthracenedione | ||
|---|---|---|---|---|
| CAS Number | 635-12-1 | Molecular Weight | 208.21200 | |
| Density | 1.328 g/cm3 | Boiling Point | 406ºC at 760 mmHg | |
| Molecular Formula | C14H8O2 | Melting Point | 217°C | |
| MSDS | N/A | Flash Point | 152ºC | |
Use of 1,4-Anthracenedione1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1]. |
| Name | 1,4-Anthraquinone |
|---|---|
| Synonym | More Synonyms |
| Description | 1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1]. |
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| Related Catalog | |
| Target |
DNA/RNA synthesis[1] |
| In Vitro | 1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4[1]. 1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal[1]. 1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM. Cell Viability Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4. |
| Density | 1.328 g/cm3 |
|---|---|
| Boiling Point | 406ºC at 760 mmHg |
| Melting Point | 217°C |
| Molecular Formula | C14H8O2 |
| Molecular Weight | 208.21200 |
| Flash Point | 152ºC |
| Exact Mass | 208.05200 |
| PSA | 34.14000 |
| LogP | 2.77500 |
| Index of Refraction | 1.702 |
| Safety Phrases | S22-S24/25 |
|---|---|
| HS Code | 2914690090 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
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CAS#:7218-35-1| HS Code | 2914690090 |
|---|---|
| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
| anthracene-1,4-dione |
| EINECS 211-228-7 |
| MFCD00013724 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 1,4-Anthracenedione
- Price: ￥778.0/100mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1,4-Anthracenedione
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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