ML328
Modify Date: 2024-01-08 20:50:40
ML328 structure
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Common Name | ML328 | ||
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| CAS Number | 634175-34-1 | Molecular Weight | 506.501 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 643.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C22H21F3N6O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 342.7±34.3 °C | |
Use of ML328ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection[1][2]. |
| Name | 8-Ethyl-5-oxo-2-(4-{[3-(trifluoromethyl)phenyl]carbamothioyl}-1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid |
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| Synonym | More Synonyms |
| Description | ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection[1][2]. |
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| Related Catalog | |
| In Vitro | ML328 (0.1-1000 μM) 具有 AddAB 和 RecBCD 核酸酶抑制活性，IC50 值分别为 26 和 5.1 μM [1]。 ML328 对 RecBCD，RecF 和 RecE 通路特异性地抑制高频重组[1]。 ML328 对 RecBCD 具有抑制作用，对 RecBCD 核酸酶、促进 Hfr 重组和噬菌体 λ 重组的 IC50 值分别为 3，0.3 和 5 μΜ[2]。 ML328 抑制 E. coli RecBCD，E. coli AddAB，M. smeg AddAB 和 M. smeg RecBCD 的 IC50 值分别为 4.6，16，2.4 和 5.5 μM[2]。 Ml328 (25 μΜ；2 h) 降低了 H2O2 诱导 E. coli 突变的频率[2]。 Ml328 (25 μΜ；1 h) 降低 H2O2 诱导 E. coli 缬氨酸抗性 (valineR) 突变的频率[2]。 ML328 (50 μΜ) 轻度抑制 E. coli 生长，但在噬菌体存在时显著抑制 E. coli 生长[2]。 |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 643.0±65.0 °C at 760 mmHg |
| Molecular Formula | C22H21F3N6O3S |
| Molecular Weight | 506.501 |
| Flash Point | 342.7±34.3 °C |
| Exact Mass | 506.134796 |
| LogP | 2.38 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.657 |
| 8-Ethyl-5-oxo-2-(4-{[3-(trifluoromethyl)phenyl]carbamothioyl}-1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid |
| Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-[4-[thioxo[[3-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- |