Ginsenoside Rh1
Modify Date: 2024-01-02 18:15:37
Ginsenoside Rh1 structure
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Common Name | Ginsenoside Rh1 | ||
|---|---|---|---|---|
| CAS Number | 63223-86-9 | Molecular Weight | 638.872 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 755.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C36H62O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 410.5±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Ginsenoside Rh1Ginsenoside Rh1 is isolated from the root of Panax Ginseng. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β. |
| Name | Ginsenoside Rh1 |
|---|---|
| Synonym | More Synonyms |
| Description | Ginsenoside Rh1 is isolated from the root of Panax Ginseng. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β. |
|---|---|
| Related Catalog | |
| Target |
PPAR-γ TNF-α IL-6 IL-1β |
| In Vitro | The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected[1]. |
| In Vivo | When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone[1]. |
| Cell Assay | Mouse embryo fibroblasts 3T3-L1 cells are incubated in DMEM, containing 10% FBS and 1% AB, at 37°C and 5.6% CO2 atmosphere. To induce differentiation, two days after confluence, preadipocytes (designated day 0) are cultured in the differentiation medium (DM), which is consisted of DMEM, 10% FBS, 1% AB, and DMI (0.28 unit/mL insulin, 0.5 mM Isobutylmethylxanthine and 1 μM Dexamethasone) for 2 d in the presence or absence of 50 μM and 100 μM of Ginsenoside Rh1, and switched to DM containing 10% FBS and 10 μg/mL insulin and then changed to DMEM medium with 10% FBS for every 2 d[1]. |
| Animal Admin | Mice[1] Male C57BL/6J mice are separated into 3 groups, LFD, HFD and HFDRh1. Each group is consisted of ten mice. LFD group fed LFD for 8 weeks. HFD group fed HFD for 8 weeks. HFDRh1 group fed HFD diet for 4 weeks and then simultaneously treated with HFD and 20 mg/kg/d Ginsenoside Rh1, which is orally administrated. Weight and food intake of mice are measured daily. After finishing treatment for 4 weeks, blood and epididymal fats are collected for further analysis. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 755.1±60.0 °C at 760 mmHg |
| Molecular Formula | C36H62O9 |
| Molecular Weight | 638.872 |
| Flash Point | 410.5±32.9 °C |
| Exact Mass | 638.439392 |
| PSA | 160.07000 |
| LogP | 3.74 |
| Vapour Pressure | 0.0±5.7 mmHg at 25°C |
| Index of Refraction | 1.581 |
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Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
J. Nat. Prod. 70(7) , 1203-6, (2007) Three 20(S)-protopanaxatriol-type saponins, ginsenoside-Rg1 (1), notoginsenoside-R1 (2), and ginsenoside-Re (3), were transformed by the fungus Absidia coerulea (AS 3.3389). Compound 1 was converted i... |
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[Studies on chemical constituents from rhizomes of Panax notoginseng].
Zhong Yao Cai 30(11) , 1388-91, (2007) To study the chemical constituents from rhizomes of Panax notoginseng.The constituents were isolated and purified by various chromatogragraphic methods, all compounds were identified on the basis of s... |
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Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice.
J. Ethnopharmacol. 142(1) , 105-112, (2012) The root of Panax ginseng CA Meyer (ginseng) has been used for diabetes, cancer, stress and allergic diseases in the traditional Chinese medicine.To understand the role of intestinal microflora in the... |
| Sanchinoside B2 |
| sanchinoside rh1 |
| GinsenosideRh1 |
| β-D-Glucopyranoside, (3β,6α,12β)-3,12,20-trihydroxydammar-24-en-6-yl |
| (3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl β-D-glucopyranoside |
- BioBioPha
- China
- Product Name: Ginsenoside Rh1
- Price: ￥Inquiry/20mg
- Purity: 98.0%
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ginsenoside Rh1
- Price: ￥398.0/20mg
- Purity: 98.0%
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- DC Chemicals Limited
- China
- Product Name: Ginsenoside Rh1
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Ginsenoside Rh1
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
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- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: TIANFU-CHEM -Ginsenoside Rh1
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: TIANFU-CHEM -Ginsenoside Rh1
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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