Benzo[b]thiophene-2-carboxamide,N-phenyl-

Modify Date: 2024-01-05 18:10:05

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure
Benzo[b]thiophene-2-carboxamide,N-phenyl- structure
Common Name Benzo[b]thiophene-2-carboxamide,N-phenyl-
CAS Number 6314-40-5 Molecular Weight 253.31900
Density 1.32g/cm3 Boiling Point 346.2ºC at 760 mmHg
Molecular Formula C15H11NOS Melting Point N/A
MSDS N/A Flash Point 163.1ºC

 Use of Benzo[b]thiophene-2-carboxamide,N-phenyl-


Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

 Names

Name N-phenyl-1-benzothiophene-2-carboxamide
Synonym More Synonyms

  Biological Activity

Description Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].
Related Catalog
Target

Aβ42 aggregation[1]

References

[1]. Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.  

 Chemical & Physical Properties

Density 1.32g/cm3
Boiling Point 346.2ºC at 760 mmHg
Molecular Formula C15H11NOS
Molecular Weight 253.31900
Flash Point 163.1ºC
Exact Mass 253.05600
PSA 57.34000
LogP 4.22660
Index of Refraction 1.735

 Safety Information

HS Code 2934999090

 Synthetic Route

~71%

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure

Benzo[b]thiophe...

CAS#:6314-40-5

Literature: Antonow, Dyeison; Marrafa, Teresa; Dawood, Irfaan; Ahmed, Tauheed; Haque, Mohammad R.; Thurston, David E.; Zinzalla, Giovanna Chemical Communications, 2010 , vol. 46, # 13 p. 2289 - 2291

~%

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure

Benzo[b]thiophe...

CAS#:6314-40-5

Literature: Goettsch; Wiese Journal of the American Pharmaceutical Association (1912-1977), 1958 , vol. 47, p. 319,320

~%

Benzo[b]thiophene-2-carboxamide,N-phenyl- Structure

Benzo[b]thiophe...

CAS#:6314-40-5

Literature: Shirley; Cameron Journal of the American Chemical Society, 1952 , vol. 74, p. 664

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

benzo[b]thiophene-2-carboxylic acid anilide
benzothiophene-2-carboxanilide
HMS3078J06
Benzo[b]thiophen-2-carbonsaeure-anilid
Benzo[b]thiophene-2-carboxanilide
2-Benzo<b>thenoyl-anilid
N-phenylbenzo[b]thiophene-2-carboxamide
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