Benzo[b]thiophene-2-carboxamide,N-phenyl-

Names

[ Name ]:
Benzo[b]thiophene-2-carboxamide,N-phenyl-

[Synonym ]:
benzo[b]thiophene-2-carboxylic acid anilide
benzothiophene-2-carboxanilide
HMS3078J06
Benzo[b]thiophen-2-carbonsaeure-anilid
Benzo[b]thiophene-2-carboxanilide
2-Benzo<b>thenoyl-anilid
N-phenylbenzo[b]thiophene-2-carboxamide

Biological Activity

[Description]:

Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Aβ42 aggregation[1]

[References]

[1]. Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
346.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁NOS

[ Molecular Weight ]:
253.31900

[ Flash Point ]:
163.1ºC

[ Exact Mass ]:
253.05600

[ PSA ]:
57.34000

[ LogP ]:
4.22660

[ Index of Refraction ]:
1.735

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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