1-MONONITROGLYCERIN

Modify Date: 2024-01-02 15:24:25

1-MONONITROGLYCERIN structure	Common Name	1-MONONITROGLYCERIN
	CAS Number	624-43-1	Molecular Weight	137.09100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃H₇NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	35.6 °F
	Symbol	GHS02, GHS07	Signal Word	Danger

Name	2,3-dihydroxypropyl nitrate
Synonym	More Synonyms

Molecular Formula	C₃H₇NO₅
Molecular Weight	137.09100
Exact Mass	137.03200
PSA	95.51000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB0200000

CHEMICAL NAME :: Glycerol, 1-nitrate

CAS REGISTRY NUMBER :: 624-43-1

BEILSTEIN REFERENCE NO. :: 1761580

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C3-H7-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 339 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1433 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
RIDADR	UN 1648 3 / PGII
Flash Point(F)	35.6 °F
Flash Point(C)	2 °C

Precursor 10
CAS#:56-81-5 Glycerol CAS#:4704-77-2 3-BROMO-1,2-PRO... CAS#:556-52-5 Glycidol CAS#:16770-74-4 ALLYLNITRATE
CAS#:55-63-0 Nitroglycerin CAS#:623-87-0 1,3-DINITROGLYCERIN CAS#:621-65-8 1,2-DINITROGLYCERIN CAS#:7697-37-2 nitric acid
CAS#:123-91-1 1,4-Dioxane CAS#:540-84-1 2,2,4-Trimethyl...
DownStream 2
CAS#:56-81-5 Glycerol CAS#:623-87-0 1,3-DINITROGLYCERIN

Studies on the biphasic relaxant curve of glyceryl trinitrate in rat aorta: role of GTN metabolites.

Clin. Exp. Pharmacol. Physiol. 16(11) , 829-35, (1989)

1. The present study has examined the possibility that one or more metabolites of glyceryl trinitrate (GTN) (i.e. glyceryl-1,2- and -1,3-dinitrate and glyceryl-1- and -2-mononitrate) may be responsibl...

Guanylate cyclase activation by organic nitrates is not mediated via nitrite.

J. Mol. Cell. Cardiol. 20(5) , 389-96, (1988)

Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence...

[Comparative pharmacology of glycerol-1-nitrate and glyceryl trinitrate in various species].

Arzneimittelforschung 36(5) , 814-21, (1986)

The present studies yield that all 4 metabolites of glyceryl trinitrate (Nitro Mack, GTN) cause the same typical pharmacological effects as the parent substance. Continuous infusion of 4 mg/kg/min of ...

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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-MONONITROGLYCERIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Precursor & DownStream

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