Mebhydrolin napadisylate

Modify Date: 2025-08-23 18:43:20

Mebhydrolin napadisylate structure	Common Name	Mebhydrolin napadisylate
	CAS Number	6153-33-9	Molecular Weight	841.048
	Density	0.9799 (rough estimate)	Boiling Point	457.3ºC at 760 mmHg
	Molecular Formula	C₄₈H₄₈N₄O₆S₂	Melting Point	280°C (rough estimate)
	MSDS	USA	Flash Point	230.4ºC

Use of Mebhydrolin napadisylate

Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist.

Name	Mebhydrolin Napadisylate
Synonym	More Synonyms

Description	Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology
Target	Histamine H1-receptor[1]
In Vitro	Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2].
References	[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7. [2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.

Density	0.9799 (rough estimate)
Boiling Point	457.3ºC at 760 mmHg
Melting Point	280°C (rough estimate)
Molecular Formula	C₄₈H₄₈N₄O₆S₂
Molecular Weight	841.048
Flash Point	230.4ºC
Exact Mass	840.301514
PSA	141.84000
LogP	10.72560
Index of Refraction	1.8676 (estimate)
InChIKey	CJUOSBUQOWKEKJ-UHFFFAOYSA-N
SMILES	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1.CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1.O=S(=O)(O)c1cccc2c(S(=O)(=O)O)cccc12

Mebhydrolin napadisylate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6845000

CAS REGISTRY NUMBER :: 6153-33-9

LAST UPDATED :: 198706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H20-N2.1/2C10-H8-O6-S2

MOLECULAR WEIGHT :: 420.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,539,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	QJ6845000
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Three explorative studies on the efficacy of the antihistamine mebhydroline (Omeril).

Int. J. Clin. Pharmacol. Ther. 33 , 373, (1995)

The efficacy of a multiple oral dose treatment with mebhydroline (Omeril coated tablets, 100 mg t.i.d.) was examined in 3 studies which were performed in a randomized, double-blind and placebo-control...

Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan.

Gastroenterology 135(1) , 111-21, (2008)

This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C v...

[Agranulocytosis associated with mebhydrolin napadisylate (Incidal)].

Harefuah 106(5) , 208-9, (1984)

Mebhydroline 1,5-naphthalenedisulfonate salt

diazoline

Naphthalene-1,5-disulfonic acid - 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1:2)

1,5-Naphthalenedisulfonic acid - 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1:2)

1,5-Naphthalenedisulfonic acid, compd. with 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-1H-pyrido[4,3-b]indole (1:2)

Mebhydrolin napadisylate

Mebhydroline Napadisylate

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Mebhydrolin napadisylate

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