Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Mebhydrolin napadisylate
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Mebhydrolin napadisylate
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DC Chemicals Limited
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Mebhydrolin napadisylate,6153-33-9
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Purity: 99.0%
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6153-33-9

6153-33-9 structure

6153-33-9 structure

Name: Mebhydrolin napadisylate
Chemical Name: Mebhydrolin Napadisylate
CAS Number: 6153-33-9
Molecular Formula: C₄₈H₄₈N₄O₆S₂
Molecular Weight: 841.048
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-07-14 18:52:06
Modify Date: 2025-08-23 18:43:20
Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist.

Name	Mebhydrolin Napadisylate
Synonyms	Mebhydroline 1,5-naphthalenedisulfonate salt diazoline Naphthalene-1,5-disulfonic acid - 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1:2) 1,5-Naphthalenedisulfonic acid - 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1:2) 1,5-Naphthalenedisulfonic acid, compd. with 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-1H-pyrido[4,3-b]indole (1:2) Mebhydrolin napadisylate Mebhydroline Napadisylate

Description	Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology
Target	Histamine H1-receptor[1]
In Vitro	Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2].
References	[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7. [2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.

Density	0.9799 (rough estimate)
Boiling Point	457.3ºC at 760 mmHg
Melting Point	280°C (rough estimate)
Molecular Formula	C₄₈H₄₈N₄O₆S₂
Molecular Weight	841.048
Flash Point	230.4ºC
Exact Mass	840.301514
PSA	141.84000
LogP	10.72560
Index of Refraction	1.8676 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6845000

CAS REGISTRY NUMBER :: 6153-33-9

LAST UPDATED :: 198706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H20-N2.1/2C10-H8-O6-S2

MOLECULAR WEIGHT :: 420.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,539,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	QJ6845000
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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