Oxythiamine chloride hydrochloride

Modify Date: 2024-01-07 21:30:51

Oxythiamine chloride hydrochloride structure	Common Name	Oxythiamine chloride hydrochloride
	CAS Number	614-05-1	Molecular Weight	351.25200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₆Cl₂N₄O₂S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Oxythiamine chloride hydrochloride

Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].

Name	oxythiamine chloride hydrochloride
Synonym	More Synonyms

Description	Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Vitamin B1, Thiamine, Transketolase[1].
In Vitro	Oxythiamine chloride hydrochloride (0-40 μM，2 天) 抑制 MIA PaCa-2 细胞的细胞活力(IC50: 14.95 μM)[1]。 Oxythiamine chloride hydrochloride (0-500 μM，48 小时) 抑制 MIA PaCa-2 细胞中 14-3-3 蛋白 beta/alpha 的表达[1]。 Oxythiamine chloride hydrochloride (0.1-100 μM, 6-48 h) 抑制 A549 细胞增殖[3]. Oxythiamine chloride hydrochloride (0.1-100 μM, 24 h) 诱导A549细胞凋亡[3]. [3]. Oxythiamine chloride hydrochloride (0-20 μM) 抑制 Lewis 肺癌 (LLC) 细胞的侵袭和迁移 (IC50: 8.75 μM)[4]。 Cell Viability Assay[1] Cell Line: MIA PaCa-2 cells Concentration: 0-40 μM Incubation Time: 2 days Result: Inhibited cell viability with an IC50 of 14.95 μM. Western Blot Analysis[1] Cell Line: MIA PaCa-2 cells Concentration: 0, 5, 50, 500 μM Incubation Time: 48 h Result: Inhibited 14-3-3 protein beta/alpha expression, and increased alpha-enolase.
In Vivo	Oxythiamine chloride hydrochloride (100-500 mg/kg，i.p. 4 天) 抑制艾氏腹水瘤宿主小鼠的肿瘤生长[2]。 Oxythiamine chloride hydrochloride (250 或 500 mg/kg，每日一次，持续 5 周) 通过抑制植入 (s.c.) LLC 细胞的小鼠体内的 MMPs 来抑制肿瘤细胞转移[4]。 Animal Model: Ehrlich's ascites tumor hosting mice[2] Dosage: 100-500 mg/kg Administration: i.p., 4 days Result: Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg.
References	[1]. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. [2]. Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. [3]. Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. [4]. Yang CM, et al. The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis. 2010 May;27(5):341-9.

Molecular Formula	C₁₂H₁₆Cl₂N₄O₂S
Molecular Weight	351.25200
Exact Mass	350.03700
PSA	107.56000

Oxythiamine chloride hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ7034100

CHEMICAL NAME :: Thiazolium, 3-((1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl)- 5-(2-hydroxyethyl)-4- methyl-, chloride, monohydrochloride

CAS REGISTRY NUMBER :: 614-05-1

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H16-N3-O2-S.Cl.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1835 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O Me zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955- Volume(issue)/page/year: 33,70,1987

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	XJ7034100
HS Code	2934100090

Thiamine

CAS#:70-16-6

Oxythiamine chl...

CAS#:614-05-1

Literature: Matsukawa; Yurugi Yakugaku Zasshi, 1951 , vol. 71, p. 827 Chem.Abstr., 1952 , p. 8125 Full Text Show Details Rydon Biochemical Journal, 1951 , vol. 48, p. 383

5-[5-(2-hydroxy...

CAS#:19030-80-9

Oxythiamine chl...

CAS#:614-05-1

Literature: Iwatsu Yakugaku Zasshi, 1952 , vol. 72, p. 366 Chem.Abstr., 1953 , p. 2179

4(1H)-Pyrimidin...

CAS#:1749-72-0

Oxythiamine chl...

CAS#:614-05-1

Literature: Slobodin; Sigel' Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 1019,1021 Chem.Abstr., 1942 , p. 6542

5-(Hydroxymethy...

CAS#:698-30-6

Oxythiamine chl...

CAS#:614-05-1

Literature: Slobodin; Sigel' Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 1019,1021 Chem.Abstr., 1942 , p. 6542

(2-methyl-6-oxo...

CAS#:5353-05-9

Oxythiamine chl...

CAS#:614-05-1

Literature: Slobodin; Sigel' Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 1019,1021 Chem.Abstr., 1942 , p. 6542

5-Pyrimidineace...

CAS#:14273-42-8

Oxythiamine chl...

CAS#:614-05-1

Literature: Slobodin; Sigel' Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 1019,1021 Chem.Abstr., 1942 , p. 6542

Sulfurol

CAS#:137-00-8

5-bromomethyl-2...

CAS#:858269-26-8

Oxythiamine chl...

CAS#:614-05-1

Literature: Slobodin; Sigel' Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 1019,1021 Chem.Abstr., 1942 , p. 6542

N-(2-methyl-6-o...

CAS#:720710-56-5

2-chloro-3-oxop...

CAS#:13051-49-5

Oxythiamine chl...

CAS#:614-05-1

Literature: Matsukawa; Yurugi Yakugaku Zasshi, 1951 , vol. 71, p. 827 Chem.Abstr., 1952 , p. 8125

N-(2-methyl-6-o...

CAS#:720710-56-5

N/A

CAS#:13110-18-4

2-chloro-3-oxop...

CAS#:13051-49-5

Oxythiamine chl...

CAS#:614-05-1

Literature: Bergel; Todd Journal of the Chemical Society, 1937 , p. 1504,1508

Precursor 8
CAS#:70-16-6 Thiamine CAS#:1749-72-0 4(1H)-Pyrimidin... CAS#:698-30-6 5-(Hydroxymethy... CAS#:14273-42-8 5-Pyrimidineace...
CAS#:137-00-8 Sulfurol CAS#:858269-26-8 5-bromomethyl-2... CAS#:720710-56-5 N-(2-methyl-6-o... CAS#:13051-49-5 2-chloro-3-oxop...
DownStream 2
CAS#:134028-70-9 oxythiamine dis... CAS#:7647-01-0 Hydrochloric acid

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Inhibition of protein phosphorylation in MIA pancreatic cancer cells: confluence of metabolic and signaling pathways.

J. Proteome Res. 9 , 980-989, (2010)

Oxythiamine (OT), a transketolase inhibitor, is known to inhibit pancreatic cancer cell proliferation. In this study, we investigated the effect of inhibition of the transketolase pathway on signaling...

The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action.

Clin. Exp. Metastasis 27 , 341-349, (2010)

This study examined the anti-metastatic effects of oxythiamine (OT) both in cell culture and in vivo. Cell culture results revealed that OT (0-20 microM) significantly inhibited the invasion and migra...

Thiazolium,3-((1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-,chloride,monohydrochloride

5-(2-Hydroxy-aethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium,Chlorid-hydrochlorid

OXYTHIAMINE CHLORIDE HCL

5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium,chloride-hydrochloride

5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride

5-[[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methyl-1H-pyrimidin-6-one,chloride,hydrochloride

thiazolium,5-(2-hydroxyethyl)-3-[(4-hydroxy-2-methyl-5-pyrimidinyl)methyl]-4-methyl-,chloride,hydrochloride(1:1:1)

MFCD00050656

DC Chemicals Limited
China
Product Name: Oxythiamine chloride hydrochloride
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Zhejiang Hangyu API Co., Ltd
China
Product Name: OXYTHIAMINE HYDROCHLORIDE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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