TYR-D-ALA-GLY-PHE-MET

Modify Date: 2024-02-02 11:15:37

TYR-D-ALA-GLY-PHE-MET Structure
TYR-D-ALA-GLY-PHE-MET structure
Common Name TYR-D-ALA-GLY-PHE-MET
CAS Number 61370-87-4 Molecular Weight 587.68800
Density 1.305g/cm3 Boiling Point 1043.8ºC at 760 mmHg
Molecular Formula C28H37N5O7S Melting Point N/A
MSDS N/A Flash Point 585.1ºC

 Use of TYR-D-ALA-GLY-PHE-MET


[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].

 Names

Name (2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Synonym More Synonyms

 TYR-D-ALA-GLY-PHE-MET Biological Activity

Description [D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].
Related Catalog
In Vivo [D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. Animal Model: Lactating rats[1] Dosage: 0.01, 0.1 and 1 μg Administration: Intracerebroventrical injection Result: Inhibited ACh-induced and suckling-induced OT release.
References

[1]. Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.

[2]. Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.

 Chemical & Physical Properties

Density 1.305g/cm3
Boiling Point 1043.8ºC at 760 mmHg
Molecular Formula C28H37N5O7S
Molecular Weight 587.68800
Flash Point 585.1ºC
Exact Mass 587.24100
PSA 225.25000
LogP 2.19680
Index of Refraction 1.602

 Synonyms

2-Ala-met-enkephalin
Dalmee
DAMET