TYR-D-ALA-GLY-PHE-MET

Modify Date: 2025-09-03 23:09:41

TYR-D-ALA-GLY-PHE-MET structure	Common Name	TYR-D-ALA-GLY-PHE-MET
	CAS Number	61370-87-4	Molecular Weight	587.68800
	Density	1.305g/cm3	Boiling Point	1043.8ºC at 760 mmHg
	Molecular Formula	C₂₈H₃₇N₅O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	585.1ºC

Use of TYR-D-ALA-GLY-PHE-MET

[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].

Name	(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Synonym	More Synonyms

Description	[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vivo	[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. Animal Model: Lactating rats[1] Dosage: 0.01, 0.1 and 1 μg Administration: Intracerebroventrical injection Result: Inhibited ACh-induced and suckling-induced OT release.
References	[1]. Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8. [2]. Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.

Density	1.305g/cm3
Boiling Point	1043.8ºC at 760 mmHg
Molecular Formula	C₂₈H₃₇N₅O₇S
Molecular Weight	587.68800
Flash Point	585.1ºC
Exact Mass	587.24100
PSA	225.25000
LogP	2.19680
Index of Refraction	1.602

2-Ala-met-enkephalin

Dalmee

DAMET

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