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TYR-D-ALA-GLY-PHE-MET

Names

[ CAS No. ]:
61370-87-4

[ Name ]:
TYR-D-ALA-GLY-PHE-MET

[Synonym ]:
2-Ala-met-enkephalin
Dalmee
DAMET

Biological Activity

[Description]:

[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[In Vivo]

[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. Animal Model: Lactating rats[1] Dosage: 0.01, 0.1 and 1 μg Administration: Intracerebroventrical injection Result: Inhibited ACh-induced and suckling-induced OT release.

[References]

[1]. Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.

[2]. Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.

Chemical & Physical Properties

[ Density]:
1.305g/cm3

[ Boiling Point ]:
1043.8ºC at 760 mmHg

[ Molecular Formula ]:
C28H37N5O7S

[ Molecular Weight ]:
587.68800

[ Flash Point ]:
585.1ºC

[ Exact Mass ]:
587.24100

[ PSA ]:
225.25000

[ LogP ]:
2.19680

[ Index of Refraction ]:
1.602

Related Compounds